Blend behavior in Tablet Press machine

Oct 06, 2004 3 Replies

Hello all,



I'm trying to find if there is any study on powder blend behavior inside the hopper near the end of compression run.



I would really be grateful if anyone can point me towards the source. I'm observing some weird results from tablets coming out at the end of compression run.



Thanks in advance..



Sincerely,



Zabed


Specialty texts that deal with 'fine particle technology', e.g., measuring powder, will also deal peripherally with the difficulty of sampling powder, because it's so easily accidentally segregated.

Basically, if you've got a hopper, you've got a guaranteed size gradient, even if the powder is otherwise homogeneous. Blends have to be worse.

It's why you see all those strange- looking (e.g.. v-shaped) powder mixers for sale in the pharmaceutical industry trade rags.

-Mike-

Thanks Mike but can you give any reference source for your comment?

Nanoparticle News:

formatting link
From the price, I'm guessing it's more about market dynamics than technology. Borrow someone else's copy. The trick is finding the someone else.

;---

See the reference list on this page:

formatting link
I have read the T. Allen book. He used to conduct courses.

;---

Google "fine particle technology" for general stuff and "fine particle handling", etc. for your particular challenges.

-Mike-

Join the Discussion

Have something to add? Share your thoughts — no account required.

Didn't find your answer?

Ask the community — no account required