I don't see the original post, so I'll throw some comments in here.
You don't mention what the cuts are for, a secure thumb grip on the back of a blade, or to actually create a saw blade. I suppose there will be some heat treatment after all the machining and handcraft work has been completed.
A vertical mill can be used if the blade is held vertically, and then you would want to cut a single groove/notch, and then advance the Z axis to the next point for the next groove/cut.
For using a V cutter on a vertical mill, you could choose a shell arbor to hold the V cutter disk. If the grooved area to be cut is straight, you could utilize several V cutters combined with some precision spacers.
If the grooved area is an arc, you're probably limited to cutting one groove at a time, unless you could build (or have made) a custom tool from several different diameters of V cutters on a shell arbor.
A more method might involve drilling a line/series of small holes which would become the valleys of the grooved area. A die filer would be handy for the finishing work, and careful cutting on a bandsaw could be helpful in removing the bulk of the waste material. A cut-off abrasive disk could be a substitute for the bandsaw.
The drilling method would allow the notches/grooves to be arranged in convex arcs, if that would be desired. I've seen numerous knife blades where the thumb notches are along a convex arc.