For a large number of holes, it is faster if you create the hole geometry as surface feature, pattern the surface feature, and do a single cutout using the mass of surface features.
As for the graphics issues, there isn't a good answer. Anytime you divide a part surface into rounded holes, the number of triangles used in the display goes up significantly - the more circular edges in the model, the higher the count. If you're in shaded mode, make sure the wireframe edges are turned off, and set the model display accuracy to the lowest level you can handle. Or simply buy a faster graphics card.
Unless you're designing FPGA connectors, that number of holes is usually for cosmetic reasons. Like the others suggested, see if a sketch or projected curve will give you the effect you want.
Dave