I really doubt if they'd handle that kind of pressure, George. Their compression strength for those loaded plastics really isn't very high. If you figure 40,000 psi over the cartridge head, and then translate that to the specific load imposed by the back of the block against the receiver, it's still quite high. It probably would pound the block back over time.
We tend to think of big cartridges as being harder for an action to handle, but the fact is that small, high-intensity cartridges typically develop more pressure. Then the size of the cartridge base enters into it. But for specific loads (psi), small, hot ones can be a problem.
.22 Hornet typically doesn't develop a lot of pressure. But a K-Hornet can.