Slight tangent to the tangent here...
There may be another issue with more powerful cartridges. Most steel barrels have a finite peak operational life of a few thousand rounds. They will still contain the bang, but throat erosion, and rifling damage take a toll on accuracy. For a typical American hunting rifle this may be the lifetime of several generations of hunter. For a targe, plinking, or combat rifle this can be much less time, because it is used a lot more. When you add hyper velocity rounds to the mix the life is severely shortened. I often wondered if that may have been why Remington discontinued the 30-06 accelerator. I suspect it was just because 223 and 22-250 was cheaper for varmint hunting.
Yeah, I know 4150 is better than 4140, and chrome lined bores have an impact on barrel life, but generally rifles used with hyper velocity ammunition will experience a much shortened barrel life.
There are alternatives of course. A heavier projectile is one. We have two ways to get a heavier projectile. Make it longer or increase the diameter. In the US for private sporting use we are limited to .50 caliber. That means make it longer. As is well documented a longer bullet requires a faster spin rate. We saw that in the M16 and AR15 class of rifles with longer heavier bullets.
Side Note: I'm pretty sure I have mentioned it here before, but my father in law, Robert F Perry, was the engineer in charge of building the M16 production line at General Motors Hydramatic. He claimed he was the one who solved the stability issue with the M16-A1 shooting longer heavier bullets by increasing the rifling rate and spinning the bullet faster.
In any case I'm moderately arm chair familiar with the issues.
The whole thing about 556/M16 being designed to tumble and maximize damage was a myth. It was a problem solved by a faster rifling rate for the heavier bullets.
Reductio Ad Absurdum: How fast do we need to spin a 4 inch bullet traveling at Mach 3 in order to stabilize it? What do we need to slow down barrel burn out if we are pushing it at Mach 6?
Its all solvable of course, but its going to take some figuring out.
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What is that? Looks like an animal was run over repeatedly by a D9 Cat.
Oh, its the Elk Jim shot with his brand new Mach 6 Ruger American rifle shooting 50 caliber 2000 grain pointed soft point boat tails at Mach 6.4.