I do this all the time.
In page setup for a layout make sure you have the right printer, sheet size,
In the "Plot Area" section > "What to Plot" choose window, and draw the
window for your sheet. Get it all centered the way you want, and print.
Your viewports can't be larger than a sheet of course. The scale in page
setup should be 1:1. But within each viewport it can be whatever you want.
Creat the viewports, arrange them in the printing area. It's also handy if
you want several identical viewports to copy one to make another.
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