Check out the mythbusters video.
It's hard to keep the water in the safe, although the methods the mythbusters used to overcome this look a bit primitive. Certainly an expanding foam in the door joints or an epoxy or similar type mixture would have provided a better result. Some of these products set up very fast. Also with the power of modern high explosives typically being in the millions of PSI at the detonation point I would question whether the water is even necessary. An explosive charge detonating in a small confined space essentially forces the container to contain the full force of the blast until the overpressure can escape through the fairly small cracks between the door and jam. This would seem a near impossible feat. The small charge used combined with the water seemed to be massive overkill here. Not just blowing the door loose but blowing it some distance, and even it appears shearing some of the massive steel locking bolts, while badly splitting and bulging the rest of the container. Considering the force it took to do all that there was clearly a lot of excess force at work here.
Damage to the contents:
The thermal lance approach to creating a hole for the explosive charge destroyed all flamable contents (big surprise) and the explosion was pretty destructive as well but if the contents were precious metals with value only as spot this damage would probably be minimal. You aren't going to destroy a gold ingot with either approach. You might melt it a little but gold is gold it can be resmelted and recast into whatever you want as many times as you want. Further the hole could be burned a bit smaller or perhaps drilled especially if filling with water quickly enough to overcome leaks were not a problem. Liquid explosives like Astrolite could be used but these are generally considered fairly exotic requiring hazardous chemicals (hydrazine) to make. Vapor explosions can also be very powerful, especially in an enclosed area and can be initiated from chemicals as common as gasoline but controlability or even getting detonation without a difficult to achieve ideal air fuel mixture could be a problem. Shaped charges are commercially available at least to anyone who can qualify for the now required federal license, which is pretty much anyone who can buy a firearm. These can be employed from outside the container which obviously saves a lot of time vs creating a hole in the container. This would probably be the way to go for the truely skilled well connected operator but relatively crude devices detonated inside the container are obviously still a threat, especially considering that coupounds such as Bullseye which has almost the same detonation velocity as TNT, if initiated with a blasting cap, commercial or improvised, are commercially available to any adult. In the end Safe's aren't very safe. If they want in they will get in. If you have a safe with anything worth protecting in it you better hide it.