In AutoCAD you are not limited to what you can plot, nor the size of the
final sheet. The latter is a limitation of your printer, and nothing that I
know of limits the first.
If you came to acad after they started calling paperspace "layouts", there
is a bias in the program you know that tends to push you in the direction of
"one sheet per layout", but you are not stuck with this. If you put two
title blocks in the same layout, with viewports within each, all you have to
do is set the thing up to plot both. Before "layouts" this would have been
called plotting by window or view.
Click to see the full signature.