I haven't seen any software (except, possibly, older stuff that has a problem with quoted-printable in general) that would fail to quote properly when replying to a post using it. Microsoft Outlook and Outlook Express, of course, don't quote properly anyway, without the use of a third-party plugin, but that's a general problem rather than being specific to some encodings - they even break when quoting posts created by their own software.
Strictly speaking, Google Groups is actually more standards-compliant in this respect than software which treats news as if it were email and uses format=flowed. QP is part of the latest Usenet standards, while f=f isn't. But f=f won't break a client that doesn't understand it - to them, it will just appear to be hardwrapped rather than softwrapped, so it degrades gracefully. QP, on the other hand, will break in clients that don't understand it, with results that vary from merely containing a few odd characters to being totally unreadable. Even that isn't a problem if authors avoid 8-bit characters (such as pound signs and curly quotes) to begin with, as QP is only invoked if and when the characters can't be displayed in 7-bit ascii.
Mark
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